College football's Week 10 brings a loaded card, and SportsLine's projection model has published picks across the board, per CBS Sports. The marquee matchup sends the No. 1 Miami Hurricanes to face the No. 11 Notre Dame Fighting Irish, while out west the No. 7 BYU Cougars meet the No. 3 Utah Utes in a top-10 rivalry clash.

The Big Ten gets a national window Saturday with the No. 12 Ohio State Buckeyes taking on the No. 23 Oregon Ducks on CBS and Paramount+, and the action starts a day early when Nebraska visits Illinois on Friday night. In the SEC, Texas travels to Missouri and Kentucky hosts Tennessee, with the model flagging best bets for each.

Basketball season crashes the party too. Friday's 2026 Hall of Fame Series in Boston features Michigan vs. UConn and Boston College vs. UMass, and the same model has published picks for both, along with Kentucky vs. James Madison in Lexington.

It's one of the busiest betting weekends of the fall: four ranked-vs-ranked or top-25 football games, a Friday-night conference matchup, and a pair of neutral-site hoops showcases, all with model-driven numbers in circulation before kickoff and tipoff.